CARLY F. HALE
- McLean title(s): Graduate Student (University of Texas Southwestern Medical Center), Neuroscience Graduate Program, Integrative Neurobiology Lab
- Email: email@example.com
- Degree(s): Carly earned her B.A. in Biochemistry in 2006 from Austin College (Sherman, TX).
- Bio: Carly joined the graduate school at UT Southwestern Medical Center in 2008 and joined the Cowan lab for her thesis work in 2009. She was also a research technician in the Cowan lab from 2006-08. Her independent research projects in the Cowan lab initially focused on the novel role of Vav Family GEFs (guanine nucleotide exchange factor) in BDNF-induced structural and functional syanpse plasticity in the hippocampus. In addition, Carly has documented learning and memory behavioral deficits in the mutant mice, as well as anxiolytic effects . More recenlty, she has focussed on the process of MEF2-induced synapse elimination, and how MEF2 and FMRP work together to regulate synapse pruning during early brain development.
- Hale, C.F., Dietz, K.C., Varela, J.A., Wood, C.B., Zirlin, B.C., Leverich, L.S., Greene, R.W., Cowan, C.W. Essential role for Vav GEFs in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. J. Neuroscience, 31(35), 12426-12436 (2011).
- Meyer, D.A., Richer, E., Benkovic, S.A., Hayashi, K., Kansy, J.W., Hale, C., Moy, L., Kim, Y., O’Callaghan, J.P., Tsai, L.-H., Greengard, P., Nairn, A.C., Cowan, C.W., Miller, D.B., Antich, P., Bibb, J.A. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc. Natl. Acad. Sci., USA, 105: 18561-6 (2008).
- Pulliparacharuvil, S.G., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G., Kumar, A., Dewey, C.M., Davis, M., Nairn, A., Greengard, P., Nestler, E.J., Cowan, C.W. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron, 59: 621-33 (2008).
- Cowan, C.W., Hale, C.F., Taniguchi, M. Regulation of synaptic connectivity with chronic cocaine. Images in Neuroscience: Tamminga, C.A. ed. Am. J. Psychiatry, 165(11): 1393 (2008). Invited Perspective.