ELENA H. CHARTOFF, PHD
- Harvard title(s): Assistant Professor of Psychiatry
- McLean title(s): Director of Neurobiology of Motivated Behavior Laboratory
- Email: email@example.com
- Telephone: (617) 855-2022
- Fax: (617) 855-2023
- Office Address: Neurobiology of Motivated Behavior Laboratory 218
Elena received her B.S. in Biology from Carnegie Mellon University and her Ph.D. in Neurobiology and Behavior from the University of Washington. Her graduate thesis examined the regulation and role of the neuropeptide neurotensin in the striatum of rodent models of psychosis. Elena then trained as a postdoctoral fellow in Bill Carlezon's laboratory at McLean Hospital where she began her work studying the neurobiological mechanisms underlying addiction and depression. As a postdoc, Elena was awarded an NRSA postdoctoral fellowship from the National Institute on Drug Abuse (NIDA) as well as the Kaneb Fellowship in Psychiatry, which specifically supports research on depression at McLean Hospital.
- Publications: Pubmed search for "Chartoff E"
- Adams MR, Brandon EP, Chartoff EH, Idzerda RL, Dorsa DM, McKnight GS. Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci U S A. 1997;94(22):12157-61.
- Chartoff EH, Ward RP, Dorsa DM. Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. J Pharmacol Exp Ther. 1999;291(2):531-7.
- Chartoff EH, Marck BT, Matsumoto AM, Dorsa DM, Palmiter RD. Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation. Proc Natl Acad Sci U S A. 2001;98(18):10451-6.
- Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003;87(1):107-18. PMID: 12969258
- Chartoff EH, Heusner CL, Palmiter RD. Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists. Neuropsychopharmacology. 2005;30(7):1324-33. PMID: 15688082
- Goussakov I, Chartoff EH, Tsvetkov E, Gerety LP, Meloni EG, Carlezon WA, Bolshakov VY. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006;23(1):239-50.
- Chartoff EH, Mague SD, Barhight MF, Smith AM, Carlezon WA. Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. J Neurosci. 2006;26(24):6450-7.
- Chartoff EH, Pliakas AM, Carlezon WA. Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences. Biol Psychiatry. 2006;59(12):1236-9.
- Carlezon WA, Chartoff EH. Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc. 2007;2(11):2987-95.
- Chartoff EH, Potter D, Damez-Werno D, Cohen BM, Carlezon WA. Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. Neuropsychopharmacology. 2008;33(11):2676-87.
- Chartoff EH, Barhight MF, Mague SD, Sawyer AM, Carlezon WA. Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. Psychopharmacology (Berl). 2009;204(2):227-239.
- Kenny PJ, Chartoff E, Roberto M, Carlezon WA, Markou A. NMDA Receptors Regulate Nicotine-Enhanced Brain Reward Function and Intravenous Nicotine Self-Administration: Role of the Ventral Tegmental Area and Central Nucleus of the Amygdala. Neuropsychopharmacology. 2009;34(2):266-281.
- Chartoff EH, Papadopolou M, Macdonald ML, Parsegian A, Potter D, Konradi CL, Carlezon WA. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol Pharmacol. 2009;75(3):704-712.
- Ebner SR, Roitman MF, Potter DN, Rachlin AB, Chartoff EH. Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens. Psychopharmacology. 2010 Jun;210(2):241-52.PMID: 20372879.
- Potter DN, Damez-Werno D, Carlezon WA Jr., Cohen BM, Chartoff EH. Repeated exposure to the kappa- opioid receptor agonist salvinorin A modulates extracellular signal regulated kinase and reward sensitivity. Biological Psychiatry. 2011. Jul. PMID: 21757186
- Chartoff EH, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA Jr. Blockade of kappa-opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology. 2011. Jun. PubMed: 21736885.