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First psychiatric hospital in New England and the third in the country established for the treatment of the mentally ill.
Established the world's first School of Nursing in a psychiatric hospital.
First U.S. psychiatric hospital to establish basic and clinicial laboratories to study the role of biological factors in mental illness.
Renowned landscape architect Fredrick Law Olmsted was instrumental in selecting the hospital's Belmont, Massachusetts site.


Established the first alcohol and drug abuse research center in a private US psychiatric hospital.
Discovered the first evidence of chemical abnormality of nerve-cell function in the brains of people with Alzheimer's disease, a finding that ultimately led to the first and only FDA-approved treatments for Alzheimer's.
First center for electron microscopy in a U.S. psychiatric hospital, providing the ability to view the structure of individual nerve cells in the brain.
Provided the first definitive report on the effects of psychoanalytic psychotherapy for persons with schizophrenia, which spurred a new generation of psychosocial treatment approaches for this disorder.
Established the nation's first and largest "brain bank" for the study of neuropsychiatric disorders.
World's first double-blind study proving that antidepressant medication is effective in treating eating disorders.
One of the earliest test sites for new psychiatric and antidepressant medication.
First clinical report on the use of beta-blockers to treat restlessness, a major side effect of antipsychotic agents.
Developed diagnostic criteria for psychotic, affective and personality disorders adopted by the American Psychiatric Association and the World Psychiatric Association.
Developed and implemented national health screenings for alcohol, depression and memory disorders.
Co-founded the Massachusetts General Hospital/McLean Hospital Psychiatry Residency Training Program, one of the most-sought after programs of its kind.
Used sophisticated microscopic techniques to determine changes in brain nerve cells that may trigger the onset of schizophrenia.
First reported use of steroids by body builders is associated with the induction of psychiatric symptoms, including violent behavior.
First to use high speed magnetic resonance brain imaging to identify regional abnormalities in brain chemistry and activation in people with schizophrenia, mood disorders, normal aging and Alzheimer's disease.
Leader in the use of magnetic resonance spectroscopy to detect drugs of abuse and therapeutic medications in the brain.
Established the nation's first mental health information center to be run for and by consumers of mental health services.

Recent Achievements

In 2002, received $45 million annually in external research funding.
In the top 15 of all hospitals worldwide receiving National Institute of Health grant support.
First mental health clinician named in the historic Boston Marathon medical team.
McLean campus included on National Register of Historic Places.
Established laboratories to find or synthesize new treatments for depression, bipolar disorder and schizophrenia not dependent on what is developed at pharmaceutical companies. The first of these treatments are currently in clinical trials.
Developed techniques for the FDA-approved transplantation of brain tissue from a non-human mammal into the human brain, holding out significant hope for the relief of the symptoms of Parkinson's disease and Huntington's disease.
Established The Pavillion, a residential program providing the highest level of diagnostic expertise, care and discretion.
Opened the world's largest psychiatric imaging facility dedicated solely to psychiatric and substance abuse research.
Dedicated a newly renovated and expanded Hall-Mercer Center for Children and Adolescents with the unique clinical and educational services for adults. Dedicated a newly renovated and expanded Hall-Mercer Center for Children and Adolescents with the unique clinical and educational services for adults.
Worked with the Commonwealth of Massachusetts to establish the Children and Adolescent Residential Disposition (CARD) Program to decrease the numbers of youngsters stuck inappropriately on inpatient psychiatric units.